ADD1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-10034
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | ADD A,ADD1,ADDA,ADDA,Adducin 1 (alpha),Alpha adducin,Alpha-adducin,Erythrocyte adducin alpha subunit,Erythrocyte adducin subunit alpha,MGC3339,MGC44427,OTTHUMP00000151163,OTTHUMP00000151164,OTTHUMP00000151165,OTTHUMP00000218664,OTTHUMP00000218665,ADD1抗体 |
| Swissprot | P35611 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human ADD1 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm>cytoskeleton. Cell membrane. |
| Tissue specificity | Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. |
