ADRM1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-52740
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | 110 kDa cell membrane glycoprotein,adhesion regulating molecule 1,Adhesion-regulating molecule 1,ADRM 1,Adrm1,ADRM1,ARM 1,ARM-1,ARM1,Gp110,hRpn13,M(r) 110,000 surface antigen,Proteasomal ubiquitin receptor ADRM1,proteasome regulatory particle non ATPase 13,Proteasome regulatory particle non-ATPase 13,Regulatory particle non ATPase 13,Rpn13,Rpn13 homolog,ADRM1抗体 |
| Swissprot | Q16186 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Fusion protein of human ADRM1 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:40-1:200 |
| Concentration | 0.54mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | The 26S proteasome is a key component of the ubiquitin-proteasome system,a process responsible for the majority of cellular protein degradation. hRpn13 (also termed ADRM1 or GP110) is a novel 46-kDa subunit of its 19S regulatory complex. hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme,UCH37,and enhances its isopeptidase activity. Overexpression of hRpn13 promotes the activity of the ubiquitin-proteasome system and modulates the influence of osteoblasts on osteoclasts by controlling the stability of regulatory proteins in osteoblasts. |
