AF/LE Purified Anti-Mouse CD40 Antibody[FGK4.5/FGK45]
| 规格： | / 50μg / 500μg / 1mg |
| 价格： | / ￥600 / ￥1960 / ￥3560 |
货号：E-AB-F10280
货期：咨询
宿主: Rat
反应性: M
应用: FCM
Overview
| Synonyms | B-cell surface antigen CD40;Bp50;CD40;CD40L receptor;Cd40;Tnfrsf5;Tumor necrosis factor receptor superfamily member 5 |
| Swissprot | P27512 |
| Source | Rat |
| Reactivity | Mouse |
| Immunogen | Recombinant Mouse CD40 protein |
| Application | FCM |
| Recommended dilution | FCM,,2 μg/mL(1×10^5-5×10^5 cells) |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Clone No | FGK4.5/FGK45 |
|---|---|
| Isotype | Rat IgG2a, κ |
| Purification | >98%, Protein A/G purified |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Storage buffer | Sterile PBS. < 1.0 EU per mg of the antibody as determined by the LAL method |
| Background | CD40 is a 48 kD type I transmembrane glycoprotein also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39), which is expressed on activated T cells, is important in costimulation and immune regulation. |
