AIF1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-16974
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | AIF 1,AIF-1,Aif1,AIF1 protein,AIF1,Allograft inflammatory factor 1,Allograft inflammatory factor 1 splice variant G,allograft inflammatory factor-1 splice variant Hara-1,balloon angioplasty responsive transcription,BART 1,G1,G1 putative splice variant of allograft inflamatory factor 1,IBA 1,IBA1,interferon gamma responsive transcript,Interferon responsive transcript 1,interferon responsive transcript factor 1,Ionized calcium binding adapter molecule 1,Ionized calcium-binding adapter molecule 1,ionized calcium-binding adapter molecule,IRT 1,IRT1,Microglia response factor,MRF1,Protein g1,AIF1抗体 |
| Swissprot | P55008 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Full length fusion protein |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-200 |
| Concentration | 0.7mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm>cytoskeleton. Cell projection>ruffle membrane. Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis. |
| Tissue specificity | Detected in T-lymphocytes and peripheral blood mononuclear cells. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. |
