APPL1 Polyclonal Antibody
规格: | / 20μL / 60μL / 120μL / 200μL |
价格: | / ¥420 / ¥1010 / ¥1640 / ¥2365 |
货号:E-AB-10172
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
Synonyms | Adapter protein containing PH domain,Adaptor Protein Containing pH Domain,Adaptor protein containing pH domain PTB domain and leucine zipper motif 1,Adaptor protein containing pH domain PTB domain and leucine zipper motif,Adaptor protein phosphotyrosine interacting with PH domain and leucine zipper 1,AKT2 INTERACTOR,APPL 1,Appl1,DCC interacting protein 13 alpha,DCC-interacting protein 13-alpha,DIP 13 alpha,DIP13 alpha,Dip13-alpha,DIP13alpha,DP13A,KIAA1428,PTB domain and leucine zipper motif 1,PTB Domain and Leucine Zipper Motif,Signaling adaptor protein DIP13alpha,APPL1抗体 |
Swissprot | Q9UKG1 |
Source | Rabbit |
Reactivity | Human,Mouse |
Immunogen | Recombinant protein of human APPL1 |
Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
Recommended dilution | WB,,1:500-1:2000;IHC,,1:100-1:300; |
Concentration | 0.1 mg/mL |
Clonality | Polyclonal |
Properties
Cellular localization | Early endosome membrane. Nucleus. Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF. |
Tissue specificity | High levels in heart, ovary, pancreas and skeletal muscle. |
Isotype | IgG |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
Background | The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. |
Images
Western Blot analysis of A172 cell using APPL1 Polyclonal Antibody at dilution of 1:600
Immunohistochemistry of paraffin-embedded Human esophagus cancer using APPL1 Polyclonal Antibody at dilution of 1:70
Immunohistochemistry of paraffin-embedded Human lung cancer using APPL1 Polyclonal Antibody at dilution of 1:70