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APPL1 Polyclonal Antibody

规格: / 20μL / 60μL / 120μL / 200μL
价格: / ¥420 / ¥1010 / ¥1640 / ¥2365

货号:E-AB-10172

宿主: Rabbit

反应性: H,M

应用: WB,IHC

  • 详情
  • Overview

    Synonyms Adapter protein containing PH domain,Adaptor Protein Containing pH Domain,Adaptor protein containing pH domain PTB domain and leucine zipper motif 1,Adaptor protein containing pH domain PTB domain and leucine zipper motif,Adaptor protein phosphotyrosine interacting with PH domain and leucine zipper 1,AKT2 INTERACTOR,APPL 1,Appl1,DCC interacting protein 13 alpha,DCC-interacting protein 13-alpha,DIP 13 alpha,DIP13 alpha,Dip13-alpha,DIP13alpha,DP13A,KIAA1428,PTB domain and leucine zipper motif 1,PTB Domain and Leucine Zipper Motif,Signaling adaptor protein DIP13alpha,APPL1抗体
    Swissprot Q9UKG1
    Source Rabbit
    Reactivity Human,Mouse
    Immunogen Recombinant protein of human APPL1
    Application WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213)
    Recommended dilution WB,,1:500-1:2000;IHC,,1:100-1:300;
    Concentration 0.1 mg/mL
    Clonality Polyclonal

    Properties

    Cellular localization Early endosome membrane. Nucleus. Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.
    Tissue specificity High levels in heart, ovary, pancreas and skeletal muscle.
    Isotype IgG
    Purification Affinity purification
    Conjugation Unconjugated
    Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
    Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
    Background The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.
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