AR Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70112
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | AIS,ANDR,Androgen nuclear receptor variant 2,Androgen receptor (dihydrotestosterone receptor,testicular feminization,spinal and bulbar muscular atrophy,Kennedy disease),Androgen receptor,androgen receptor splice variant 4b,AR,AR8,DHTR,Dihydro testosterone receptor,Dihydrotestosterone receptor (DHTR),Dihydrotestosterone receptor,HUMARA,HYSP1,KD,Kennedy disease (KD),NR3C4,Nuclear receptor subfamily 3 group C member 4 (NR3C4),Nuclear receptor subfamily 3 group C member 4,SBMA,SMAX1,Spinal and bulbar muscular atrophy (SBMA),Spinal and bulbar muscular atrophy,Testicular Feminization (TFM),TFM,AR抗体 |
| Swissprot | P10275,P19091,P15207 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse Androgen receptor |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:300-1:1000 |
| Concentration | 0.83 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm, Nucleus |
| Tissue specificity | Isoform 2 is mainly expressed in heart and skeletal muscle (PubMed:15634333). Isoform 3 is expressed by basal and stromal cells of prostate (at protein level) (PubMed:19244107).Highest expression level in uterine cervix. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain.The protein functions as a steroid-hormone activated transcription factor.Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes.This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. |
Images
Immunohistochemistry analysis of paraffin-embedded human Prostate using AR Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded mouse seminal vesicle using AR Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded rat testis using AR Polyclonal Antibody at dilution of 1:300.
