ATF6B Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18330
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | ATF6B,CREBL1,G13,Cyclic AMP-dependent transcription factor ATF-6 beta,cAMP-dependent transcription factor ATF-6 beta,Activating transcription factor 6 beta,ATF6-beta,Protein G13,cAMP response element-binding protein-related protein;,ATF6B抗体 |
| Swissprot | Q99941 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ATF6B |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:25-1:100; |
| Concentration | 0.5mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Endoplasmic reticulum,endoplasmic reticulum membrane,integral component of endoplasmic reticulum membrane,Golgi apparatus,Golgi apparatus,Nucleus,nucleolus,RNA polymerase II transcription factor complex,Other locations:intracellular,protein-DNA complex |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. |
