ATM Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-19625
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | A-T mutated,A-T mutated homolog,AT mutated,AT1,ATA,Ataxia telangiectasia mutated,Ataxia telangiectasia mutated gene,Ataxia telangiectasia mutated homolog (human),Ataxia telangiectasia mutated homolog,ATC,ATD,ATDC,ATE,ATM,ATM serine/threonine kinase,ATM,DKFZp781A0353,MGC74674,OTTHUMP00000232981,Serine protein kinase ATM,Serine-protein kinase ATM,Serine/threonine-protein kinase ATM,Tefu,TEL1,TEL1,telomere maintenance 1,homolog,TELO1,Telomere fusion protein,ATM抗体 |
| Swissprot | Q13315 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human ATM |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:40-1:200 |
| Concentration | 1.2mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Cytoplasmic vesicle. Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. |
