ATR Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-53308
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | Ataxia telangiectasia and Rad3 related,Ataxia telangiectasia and Rad3-related protein,ATR,ATR,FCTCS,FRAP Related Protein 1,FRAP-related protein 1,FRP1,MEC1,MEC1 mitosis entry checkpoint 1 homolog,Protein kinase ATR,RAC3,Rad3 related protein,SCKL,SCKL1,Serine/threonine protein kinase ATR,Serine/threonine-protein kinase ATR,ATR抗体 |
| Swissprot | Q13535 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human ATR |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:40-1:200 |
| Concentration | 1.1mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Nucleus>PML body. Depending on the cell type, it can also be found in PML nuclear bodies. Recruited to chromatin during S-phase. Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. |
