BAD Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70084
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | AI325008,BAD,BAD,BBC 2,BBC2,BBC6,Bcl 2 Antagonist of Cell Death,Bcl 2 Binding Component 6,BCL X / BCL 2 Binding Protein,BCL X Binding Protein,Bcl XL/Bcl 2 Associated Death Promoter,Bcl-2-binding component 6,Bcl-2-like protein 8,Bcl-XL/Bcl-2-associated death promoter,Bcl2 antagonist of cell death,BCL2 antagonist of cell death protein,BCL2 associated agonist of cell death,Bcl2 Associated Death Promoter,BCL2 binding component 6,BCL2 binding protein,Bcl2 Like 8 Protein,Bcl2-L-8,BCL2L8,Proapoptotic BH3 Only Protein,BAD抗体 |
| Swissprot | Q92934,Q61337,O35147 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse Bad |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:300 |
| Concentration | 300 μg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Mitochondrion outer membrane. Cytoplasm. Upon phosphorylation, locates to the cytoplasm. |
| Tissue specificity | Expressed in a wide variety of tissues.Highest expression level in dorsolateral prefrontal cortex. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. |
Images
Immunohistochemistry analysis of paraffin-embedded human colon using BAD Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded human stomach cancer using BAD Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded mouse lung using BAD Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded rat spleen using BAD Polyclonal Antibody at dilution of 1:300.
