BAIAP2L1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18531
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | BAI1 associated protein 2 like 1,BAI1 associated protein 2 like protein 1,BAI1-associated protein 2-like protein 1,Baiap2l1,BI2L1,Brain specific angiogenesis inhibitor 1 associated protein 2 like protein 1,Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1,FLJ42275,Insulin receptor tyrosine kinase substrate,IRTKS,BAIAP2L1抗体 |
| Swissprot | Q9UHR4 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Fusion protein of human BAIAP2L1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:1000-1:5000;IHC,,1:30-1:150; |
| Concentration | 0.7mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm, cytoskeleton. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. |
