BUB1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11014
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | Bub1,BUB1 budding uninhibited by benzimidazoles 1 homolog,BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast),BUB1 mitotic checkpoint serine/threonine kinase,BUB1,S. cerevisiae,homolog of,BUB1,BUB1A,BUB1L,Budding uninhibited by benzimidazoles 1 (yeast homolog),Budding uninhibited by benzimidazoles 1 homolog,Budding uninhibited by benzimidazoles 1,S. cerevisiae,homolog of,hBUB1,Homolog of mitotic checkpoint gene BUB1,Mitotic checkpoint gene BUB1,Mitotic checkpoint serine/threonine protein kinase BUB1,Mitotic checkpoint serine/threonine-protein kinase BUB1,Mitotic spindle checkpoint kinase,Putative serine/threonine protein kinase,BUB1抗体 |
| Swissprot | O43683 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human BUB1 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.5 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Chromosome>centromere>kinetochore. Nuclear in interphase cells. Accumulates gradually during G1 and S phase of the cell cycle, peaks at G2/M, and drops dramatically after mitosis. Localizes to the outer kinetochore. Kinetochore localization is required for normal mitotic timing and checkpoint response to spindle damage and occurs very early in prophase. AURKB, CASC5 and INCENP are required for kinetochore localization. |
| Tissue specificity | High expression in testis and thymus, less in colon, spleen, lung and small intestine. Expressed in fetal thymus, bone marrow, heart, liver, spleen and thymus. Expression is associated with cells/tissues with a high mitotic index. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. |
