CASP1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18207
宿主: Rabbit
反应性: H
应用: WB,IHC
Overview
| Synonyms | CASP-1,CASP1,CASP1,Caspase 1,Caspase-1 subunit p10,ICE,IL-1 beta-converting enzyme,IL-1BC,IL1 beta converting enzyme,IL1B convertase,Interleukin 1 beta convertase,Interleukin 1B converting enzyme,Interleukin-1 beta convertase,Interleukin-1 beta-converting enzyme,p45,CASP1抗体 |
| Swissprot | P29466 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Fusion protein of human CASP1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:1000-1:4000;IHC,,1:25-1:100 |
| Concentration | 0.4mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. |
