CCDC88A Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-13059
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
| Synonyms | AKT iphosphorylation enhancer,Akt phosphorylation enhancer,APE,Ccdc88a,Coiled coil domain containing 88A,Coiled coil domain containing protein 88A,Coiled-coil domain-containing protein 88A,FLJ10392,G alpha interacting vesicle associated protein,G alpha-interacting vesicle-associated protein,Galpha interacting vesicle associated protein,Girders of actin filament,Girdin,GIV,GRDN,GRDN,HkRP1,Hook related protein 1,Hook-related protein 1,KIAA1212,CCDC88A抗体 |
| Swissprot | Q3V6T2 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide of human CCDC88A |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 1 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Membrane. Cell membrane. Cytoplasm>cytosol. Cytoplasmic vesicle. Cell projection>lamellipodium. Localizes to the cell membrane through interaction with phosphoinositides. |
| Tissue specificity | Expressed ubiquitously. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
