CD169 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70160
宿主: Rabbit
反应性: H,R
应用: IHC
Overview
| Synonyms | CD169,CD169 antigen,dJ1009E24.1,DKFZp667F058,FLJ00051,FLJ00055,FLJ00073,FLJ00411,FLJ32150,Sialic acid binding Ig like lectin 1,sialic acid binding Ig-like lectin 1,sialoadhesin,Sialic acid binding immunoglobulin like lectin 1,Sialic acid-binding Ig-like lectin 1,Sialoadhesin,Siglec 1,Siglec-1,Siglec1,SN,SN,CD169抗体 |
| Swissprot | Q9BZZ2,Q62230 |
| Source | Rabbit |
| Reactivity | Human,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse CD169 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:200-1:800 |
| Concentration | 1.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted and Cell membrane. |
| Tissue specificity | Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.Highest expression level in tendon. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined.SIGLEC1 (Sialic Acid Binding Ig Like Lectin 1) is a Protein Coding gene. Diseases associated with SIGLEC1 include Proliferative Glomerulonephritis and Diffuse Cutaneous Systemic Sclerosis. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CD22. |
