CD1B Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-17775
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | A1 domain,CD1,CD1A,CD1b,CD1b antigen,CD1B antigen b polypeptide,CD1b molecule,CD1B,Cortical thymocyte antigen CD1A,Cortical thymocyte antigen CD1B,Differentiation antigen CD1 alpha 3,hTa1 thymocyte antigen,Ly38,Ly38,T cell surface glycoprotein CD1a,MGC125990,MGC125991,R1,T-cell surface glycoprotein CD1b,T6/Leu6,Thymocite antigen CD1B,CD1B抗体 |
| Swissprot | P29016 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human CD1B |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:300 |
| Concentration | 1.4mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. Endosome membrane. Lysosome membrane. Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes. Localizes to cell surface lipid rafts. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | CD1B (CD1b Molecule) is a Protein Coding gene. Diseases associated with CD1B include Mycobacterium Malmoense and Immune System Organ Benign Neoplasm. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System. GO annotations related to this gene include beta-2-microglobulin binding and endogenous lipid antigen binding. An important paralog of this gene is CD1C.This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. |
