CD31 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70020
宿主: Rabbit
反应性: H,M,R
应用: WB
Overview
| Synonyms | Adhesion molecule,CD31,CD31 antigen,CD31 EndoCAM,EndoCAM,FLJ34100,FLJ58394,GPIIA,GPIIA',PECA1,PECA1,Pecam 1,PECAM 1 CD31 EndoCAM,PECAM,PECAM-1,Pecam1,Platelet and endothelial cell adhesion molecule 1,Platelet endothelial cell adhesion molecule,Platelet/endothelial cell adhesion molecule 1,CD31抗体 |
| Swissprot | P16284,Q08481,Q3SWT0 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse CD31 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.88 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Membrane |
| Tissue specificity | Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells . Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level). Expressed on neutrophils (at protein level) . Isoform Long predominates in all tissues examined . Isoform Delta12 is detected only in trachea . Isoform Delta14-15 is only detected in lung . Isoform Delta14 is detected in all tissues examined with the strongest expression in heart . Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level).Highest expression level in tendon of biceps brachii. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | Platelet endothelial cell adhesion molecule-1 (PECAM-1,CD31) is a member of the immunoglobulin gene superfamily of cell adhesion molecules. It is highly expressed on the surface of the endothelium,making up a large portion of its intracellular junctions. PECAM-1 is also present on the surface of hematopoietic cells and immune cells including platelets,monocytes,neutrophils,natural killer cells,megakaryocytes and some types of T-cell . As well as its role in cell-cell adhesion,PECAM-1 functions as a signaling receptor,and is involved in important physiological events such as nitric oxide production,regulation of T-cell immunity and tolerance,leukocyte transendothelial migration and inflammation and angiogenesis . |
