CD42b Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11281
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | Antigen CD42b alpha,BDPLT1,BDPLT3,BSS,CD 42b,CD42b alpha,CD42B,CD42b antigen,DBPLT3,GLYCOCALICIN,Glycoprotein Ib (platelet) alpha polypeptide,Glycoprotein Ibalpha,GP Ib alpha,GP1B,GP1BA,GPIb alpha,GPIbA,MGC34595,Platelet glycoprotein Ib alpha chain,Platelet glycoprotein Ib alpha polypeptide,Platelet membrane glycoprotein 1b alpha subunit,VWDP,GP1BA抗体 |
| Swissprot | P07359 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant protein of human GP1BA |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:100-1:300; |
| Concentration | 0.8 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell Membrane |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. |
Images
Western Blot analysis of Mouse liver tissue using CD42b Polyclonal Antibody at dilution of 1:800
Immunohistochemistry of paraffin-embedded Human liver cancer using CD42b Polyclonal Antibody at dilution of 1:60
Immunohistochemistry of paraffin-embedded Spleen tissue using CD42b Polyclonal Antibody at dilution of 1:80(Elabscience® Product Detected by Lifespan).
