CD4 Monoclonal Antibody
| 规格： | / 20μL / 60μL / 120μL |
| 价格： | / ￥580 / ￥1420 / ￥2310 |
货号：E-AB-22098
宿主: Mouse
反应性: H,M,R
应用: IHC-p,IF
Overview
| Synonyms | CD 4,CD4 (L3T4),CD4,CD4 antigen (p55),CD4 antigen,CD4 molecule,CD4 receptor,CD4+ Lymphocyte deficiency,included,CD4,CD4mut,L3T4,Leu3,Ly-4,Lymphocyte antigen CD4,MGC165891,OTTHUMP00000238897,p55,T cell antigen T4,T cell antigen T4/LEU3,T cell differentiation antigen L3T4,T cell OKT4 deficiency,included,T cell surface antigen T4/Leu 3,T cell surface antigen T4/Leu3,T cell surface glycoprotein CD4,T-cell surface antigen T4/Leu-3,T-cell surface glycoprotein CD4,W3/25,W3/25 antigen,CD4抗体 |
| Swissprot | P01730 |
| Source | Mouse |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic Peptide |
| Application | IHC-p(Detection kit: E-IR-R213),IF |
| Recommended dilution | IHC,,1:100-1:300;IF,,1:50-200; |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Cellular localization | Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum. |
| Tissue specificity | Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells. |
| Clone No | Clone:9G1 |
|---|---|
| Isotype | IgG |
| Purification | Protein A purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.4 |
| Background | This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. |
Images
Immunohistochemistry of paraffin-embedded Human stomach tissue using CD4 Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Mouse brain tissue using CD4 Monoclonal Antibody at dilution of 1:200.
Immunofluorescence analysis of Mouse colonic tissue with CD4 Monoclonal Antibody.
