CD89 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15027
宿主: Rabbit
反应性: H
应用: WB,IHC
Overview
| Synonyms | CD89,Fc alpha receptor,Fc fragment of IgA,receptor for,FCAR,FCAR,IgA Fc receptor,Immunoglobulin alpha Fc receptor,FCAR抗体 |
| Swissprot | P24071 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human FCAR |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.2 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted and Cell membrane. |
| Tissue specificity | Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
Images
Western Blot analysis of 293T cell and Mouse brain tissue using CD89 Polyclonal Antibody at dilution of 1:550
Immunohistochemistry of paraffin-embedded Human liver cancer using CD89 Polyclonal Antibody at dilution of 1:20
Immunohistochemistry of paraffin-embedded Human prostate cancer using CD89 Polyclonal Antibody at dilution of 1:20
