CENPF Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-53524
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | AH antigen,Cell cycle dependent 350K nuclear protein,CENF,CENP F,CENP F kinetochore protein,CENP-F,CENPF,CENPF kinetochore protein,CENPF,Centromere protein F 350/400ka,Centromere protein F,Centromere protein F,350/400kDa,CILD31,Hcp 1,Hcp1,Kinetochore protein CENP F,Kinetochore protein CENPF,Mitosin,PRO1779,STROMS,CENPF抗体 |
| Swissprot | P49454 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human CENPF |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:30-1:150 |
| Concentration | 1.3mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm, perinuclear region. Nucleus matrix. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Relocalizes to the kinetochore/centromere (coronal surface of the outer plate) and the spindle during mitosis. Observed in nucleus during interphase but not in the nucleolus. At metaphase becomes localized to areas including kinetochore and mitotic apparatus as well as cytoplasm. By telophase, is concentrated within the intracellular bridge at either side of the mid-body. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. |
