CGAS Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-17843
宿主: Rabbit
反应性: H
应用: WB
Overview
| Synonyms | C6orf150,cGAMP synthase,cGAS,CGAS,cGMP Synthase,Chromosome 6 open reading frame 150,Cyclic GMP-AMP synthase,h-cGAS,Hypothetical protein LOC115004,Mab 21 domain containing 1,Mab-21 domain-containing protein 1,MB21D1,MGC131892,MGC142166,MGC142168,OTTHUMP00000016743,OTTHUMP00000039330,protein MB21D1,Uncharacterized protein C6orf150,CGAS抗体 |
| Swissprot | Q8N884 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human MB21D1 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.78mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm>cytosol. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115). |
