CHOP Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70087
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | C/EBP homologous protein,C/EBP Homology Protein,C/EBP zeta,C/EBP-homologous protein 10,C/EBP-homologous protein,CCAAT/enhancer binding protein homologous protein,CEBPZ,CHOP 10,CHOP,CHOP-10,CHOP10,DDIT 3,DDIT-3,Ddit3,DDIT3,DNA Damage Inducible Transcript 3,DNA damage-inducible transcript 3 protein,GADD 153,GADD153,Growth Arrest and DNA Damage Inducible Protein 153,Growth arrest and DNA damage inducible protein GADD153,Growth arrest and DNA damage-inducible protein GADD153,MGC4154,CHOP抗体 |
| Swissprot | P35638,P35639,Q62857 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse CHOP |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100-500 |
| Concentration | 1 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm, Nucleus |
| Tissue specificity | Highest expression level in hypothalamus |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | CHOP,also known as GADD153 or DDIT3,is a highly conserved gene in both the structural and regulatory regions to hamster gene.Imposed by unfolded and malfolded proteins,CHOP is significantly induced by ER stress,deficiency of CHOP prevents cell from ER stress. CHOP is considered a proapoptotic marker of ER stress dependent cell death. CHOP acts as a dominant-negative inhibitor of the transcription factor C/EBP and LAP by forming a heterodimer. It may play an important role in the malignant transformation of nevus to melanoma. |
Images
Immunohistochemistry analysis of paraffin-embedded human colon using CHOP Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded human stomach cancer using CHOP Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded mouse brain using CHOP Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded Rat brain using CHOP Polyclonal Antibody at dilution of 1:300.
