COMP Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11095
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | cartilage oligomeric matrix protein (pseudoachondroplasia,epiphyseal dysplasia 1,multiple),Cartilage oligomeric matrix protein,Cartilage oligomeric matrix protein precursor,COMP,COMP,EDM 1,EDM1,EPD 1,EPD1,Epiphyseal dysplasia 1,Epiphyseal dysplasia 1 multiple,Epiphyseal dysplasia multiple 1,MED,MGC13181,MGC149768,PSACH,pseudoachondroplasia (epiphyseal dysplasia 1,multiple),Pseudoachondroplasia,THBS 5,THBS5,Thrombospondin 5,Thrombospondin-5,Thrombospondin5,TSP5,COMP抗体 |
| Swissprot | P49747 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human COMP |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:50-1:200; |
| Concentration | 0.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted>extracellular space>extracellular matrix. |
| Tissue specificity | Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). |
