COX7A2L Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-52144
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
| Synonyms | COX7a related protein,COX7a-related protein,COX7A2L,COX7AR,COX7R,COX7RP,Cytochrome c oxidase subunit 7A-related protein,cytochrome c oxidase subunit 7A-related protein, mitochondrial,Cytochrome c oxidase subunit 7A2 like,cytochrome c oxidase subunit VII-related protein,cytochrome c oxidase subunit VIIa polypeptide 2 like,Cytochrome c oxidase subunit VIIa related protein, mitochondrial,Cytochrome c oxidase subunit VIIa-related protein,EB1,Estrogen receptor binding CpG island,mitochondrial,SIG81,COX7A2L抗体 |
| Swissprot | O14548 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:30-1:150 |
| Concentration | 2.5mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Mitochondrion inner membrane. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. |
