CREBBP Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-52070
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | CBP,CBP,CREB binding protein,CREB-binding protein,Crebbp,Cyclic AMP responsive enhancer binding protein,KAT3A,RSTS,RTS,Rubinstein Taybi syndrome,CREBBP抗体 |
| Swissprot | Q92793 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human CREBBP |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:30-1:150 |
| Concentration | 0.96mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors.First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition.The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex.This protein acetylates both histone and non-histone proteins.This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain.Mutations in this gene cause Rubinstein-Taybi syndrome (RTS).Chromosomal translocations involving this gene have been associated with acute myeloid leukemia.Alternative splicing results in multiple transcript variants encoding different isoforms. |
