CREBZF Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-53232
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | 1110034C16Rik,6330417B10Rik,AI225749,AI606244,CREB/ATF bZIP transcription factor,Crebzf,FLJ94018,HCF-binding transcription factor Zhangfei,Host cell factor-binding transcription factor Zhangfei,LAZip,LAZipII,SHP-interacting leucine zipper protein,SMILE,ZF,ZHANG,CREBZF抗体 |
| Swissprot | Q9NS37 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CREBZF |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:25-1:100; |
| Concentration | 0.4mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Colocalizes at punctate nuclear structures with CREB3 and HCFC1. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Host cell factor (HCF) is a cellular cofactor required for the activation of VP16 which expresses the herpes simplex virus immediate early gene. V16 binds to HCF through a 4-amino acid motif similar to the HCF binding domain of the basic leucine-zipper proteins Luman and Zhangfei (ZF). Luman activates promoters containing cAMP or unfolded protein response elements (UPRE). Zhangfei suppresses the transcriptional activity of Luman, but requires HCF binding which may target Luman and Zhangfei to a common location. Sequence analysis predicts that the deduced 272-amino acid Zhangfei protein has a negatively charged N terminus, a leucine zipper of 6 heptad leucine repeats separated by a conserved 6-amino acid spacer, a basic domain, and a bZIP region. It is also presumed that the N-terminal acidic region of Zhangfei is an activation domain. |
