Cyclin E1 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70166
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | CCNE,Ccne1,CCNE1,cyclin E variant ex5del,cyclin E variant ex7del,Cyclin E1,Cyclin Es,Cyclin Et,CyclinE,G1/S specific cyclin E,G1/S-specific cyclin-E1,Cyclin E1抗体 |
| Swissprot | P24864,Q61457 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse Cyclin E1 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:300-1:1000 |
| Concentration | 0.98 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. |
| Tissue specificity | Highly expressed in testis and placenta. Low levels in bronchial epithelial cells. Highest expression level in secondary oocyte. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. |
