DRG1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14961
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | Developmentally regulated GTP binding protein 1,Developmentally-regulated GTP-binding protein 1,DKFZp434N1827,DRG 1,DRG-1,DRG1,DRG1,NEDD 3,NEDD-3,NEDD3,Neural precursor cell expressed developmentally down regulated protein 3,Neural precursor cell expressed developmentally down-regulated protein 3,DRG1抗体 |
| Swissprot | Q9Y295 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant protein of human DRG1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.6 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. |
| Tissue specificity | High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | DRG1 (developmentally regulated GTP binding protein 1), also known as NEDD3 (neural precursor cell expressed developmentally down-regulated protein 3), is a 367 amino acid protein that localizes to the cytoplasm and belongs to the GTP1/OBG family. Expressed at high levels in heart, kidney and skeletal muscle and at lower levels in brain, liver, placenta, lung, colon and spleen, DRG1 binds to TAL1 and TAL2 and is thought to play a role in cell proliferation and differentiation, as well as in apoptosis, suggesting a role in tumor formation and metastasis. DRG1 is subject to polyubiquitination and sumoylation, the former of which induces proteolytic degradation. The gene encoding DRG1 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. |
Images
Western Blot analysis of Human fetal brain tissue using DRG1 Polyclonal Antibody at dilution of 1:500
Immunohistochemistry of paraffin-embedded Human tonsil using DRG1 Polyclonal Antibody at dilution of 1:20
Immunohistochemistry of paraffin-embedded Human liver cancer using DRG1 Polyclonal Antibody at dilution of 1:20
