DROSHA Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-17893
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
| Synonyms | DROSHA,Drosha double stranded RNA specific endoribonuclease,Drosha ribonuclease type III,Etohi2,HSA242976,Nuclear RNase III Drosha,p241,Protein Drosha,Putative protein p241 which interacts with transcription factor Sp1,Putative ribonuclease III,RANSE3L,Ribonuclease 3,Ribonuclease III,Ribonuclease III nuclear,Ribonuclease type III nuclear,RibonucleaseIII,RN 3,RN3,RNase 3,RNase III,RNase3,RNASE3L,RNaseIII,RNASEN,RNC,DROSHA抗体 |
| Swissprot | Q9NRR4 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human DROSHA |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:30-1:150 |
| Concentration | 1.74mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Nucleus>nucleolus. A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. DROSHA (Drosha Ribonuclease III) is a Protein Coding gene. Diseases associated with DROSHA include Combat Disorder and Murray Valley Encephalitis. Among its related pathways are mRNA Capping and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and RNA binding. |
