DUSP22 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14065
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
| Synonyms | Dual specificity protein phosphatase 22,DUS22,Dusp22,JNK stimulatory phosphatase 1,JNK-stimulatory phosphatase-1,JSP 1,JSP-1,JSP1,LMW DSP2,LMW-DSP2,Low molecular weight dual specificity phosphatase 2,MAP kinase phosphatase x,Mitogen activated protein kinase phosphatase x,Mitogen-activated protein kinase phosphatase x,MKP-x,MKPX,DUSP22抗体 |
| Swissprot | Q9NRW4 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant protein of human DUSP22 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. |
| Tissue specificity | Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. DUSP22 dephosphorylates ERK2 MAP kinase and JNK. DUSP22 displays highest in thymus, but it is also detectable in monocytes and lymphocytes. |
