E-Cadherin Monoclonal Antibody
| 规格： | / 60μL / 120μL |
| 价格： | / ￥1420 / ￥2310 |
货号：E-AB-70249
宿主: Mouse
反应性: M,R
应用: IHC
Overview
| Synonyms | Arc 1,CADH1,Cadherin 1,cadherin 1 type 1 E-cadherin,Cadherin1,CAM 120/80,CD 324,CD324,CD324 antigen,cdh1,CDHE,E-Cad/CTF3,E-cadherin,ECAD,Epithelial cadherin,epithelial calcium dependant adhesion protein,LCAM,Liver cell adhesion molecule,UVO,Uvomorulin,E-Cadherin抗体 |
| Swissprot | P09803,Q9R0T4 |
| Source | Mouse |
| Reactivity | Mouse,Rat |
| Immunogen | Recombinant protein corresponding to MouseE-cadherin |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:200-1:800 |
| Concentration | 1.6 mg/mL |
| Clonality | Monoclonal |
Properties
| Clone No | EC125D |
|---|---|
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. |
Images
Immunohistochemistry analysis of paraffin-embedded mouse liver using E-Cadherin Monoclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded rat colon using E-Cadherin Monoclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded rat pancreas using E-Cadherin Monoclonal Antibody at dilution of 1:300.
