ELF3 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-52915
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | E74 like factor 3,E74 like factor 3 ets domain transcription factor,E74 like factor 3 ets domain transcription factor epithelial specific,E74 like factor 3 ETS domain transcription factor serine box epithelial specific,E74-like factor 3,Elf3,ELF3,Epithelial restricted with serine box ,Epithelial-restricted with serine box,Epithelium restricted Ets protein ESX,Epithelium specific Ets factor 1,Epithelium specific Ets transcription factor 1,Epithelium-restricted Ets protein ESX,Epithelium-specific Ets transcription factor 1,EPR 1,EPR1,ERT,ESE-1,ESX,Ets domain transcription factor serine box,Ets domain transcription factor serine box epithelial specific,Ets transcription factor,ETS-related transcription factor Elf-3,jen,MGC139318,ELF3抗体 |
| Swissprot | P78545 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Fusion protein of human ELF3 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:300 |
| Concentration | 1.02mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). |
