ERG Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14117
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | Avian erythroblastosis virus E-26 (v-ets) oncogene related,D030036I24Rik,Erg 3,Erg,ERG/EWS fusion gene,included,ERG/FUS fusion gene,included,ERG/TMPSSR2 fusion gene,included,ERG,ERG1,included,ERG2,included,ets related,ETS-related gene,KCNH2,Oncogene ERG,p55,TMPRSS2/ERG fusion,transcriptional regulator ERG (transforming protein ERG),Transcriptional regulator ERG,Transforming protein ERG,v ets avian erythroblastosis virus E26 oncogene,v ets avian erythroblastosis virus E26 oncogene related,v ets erythroblastosis virus E26 oncogene homolog,v ets erythroblastosis virus E26 oncogene like,v ets erythroblastosis virus E26 oncogene like isoform 2,v-ets erythroblastosis virus E26 oncogene,v-ets erythroblastosis virus E26 oncogene homolog (avian),V-ets erythroblastosis virus E26 oncogene like (Avian),isoform CRA_e,ERG抗体 |
| Swissprot | P11308 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant protein of human ERG |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:50-1:200; |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. |
Images
Western Blot analysis of 293T cell using ERG Polyclonal Antibody at dilution of 1:650
Immunohistochemistry of paraffin-embedded Mouse brain using ERG Polyclonal Antibody at dilution of 1:50
Immunohistochemistry of paraffin-embedded Human lung cancer using ERG Polyclonal Antibody at dilution of 1:40
