FAS Monoclonal Antibody
| 规格： | / 60μL / 120μL |
| 价格： | / ￥1420 / ￥2310 |
货号：E-AB-70174
宿主: Mouse
反应性: H,M
应用: IHC
Overview
| Synonyms | ALPS 1A,ALPS1A,APO 1,Apo 1 antigen,APO 1 cell surface antigen,Apo-1 antigen,APO1,Apo1 antigen,APO1 cell surface antigen,Apoptosis antigen 1,Apoptosis mediating surface antigen FAS,Apoptosis-mediating surface antigen FAS,APT 1,APT1,CD 95,CD 95 antigen,CD95,CD95 antigen,Delta Fas,Delta Fas/APO 1/CD95,Delta Fas/APO1/CD95,Fas (TNF receptor superfamily,member 6),FAS 1,FAS 827dupA,Fas AMA,Fas,FAS Antigen,Fas cell surface death receptor,FAS1,FASLG receptor,FASTM,sFAS,Surface antigen APO1,TNF receptor superfamily,member 6,TNFRSF 6,TNFRSF6,TNR6,Tumor necrosis factor receptor superfamily member 6,FAS抗体 |
| Swissprot | P25445,P25446 |
| Source | Mouse |
| Reactivity | Human,Mouse |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse FAS |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:200-1:800 |
| Concentration | 420 μg/mL |
| Clonality | Monoclonal |
Properties
| Clone No | 10E5B10 |
|---|---|
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | FAS,also named as CD95,APO-1,APT1,FAS1 and TNFRSF6,is a receptor for TNFSF6/FASLG. It is a cell surface receptor belonging to the TNF receptor superfamily,can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains,leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance,in the antigen-stimulated suicide of mature T-cells,or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). This anti-Fas monoclonal antibody can be used to induce apoptosis in cell cultures through Fas by imitating the Fas-ligand. |
Images
Immunohistochemistry analysis of paraffin-embedded human gallbladder using FAS Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry analysis of paraffin-embedded mouse colon using FAS Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry analysis of paraffin-embedded mouse testis using FAS Monoclonal Antibody at dilution of 1:200.
