FAS Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70336
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | ALPS 1A,ALPS1A,APO 1,Apo 1 antigen,APO 1 cell surface antigen,Apo-1 antigen,APO1,Apo1 antigen,APO1 cell surface antigen,Apoptosis antigen 1,Apoptosis mediating surface antigen FAS,Apoptosis-mediating surface antigen FAS,APT 1,APT1,CD 95,CD 95 antigen,CD95,CD95 antigen,Delta Fas,Delta Fas/APO 1/CD95,Delta Fas/APO1/CD95,Fas (TNF receptor superfamily,member 6),FAS 1,FAS 827dupA,Fas AMA,Fas,FAS Antigen,Fas cell surface death receptor,FAS1,FASLG receptor,FASTM,sFAS,Surface antigen APO1,TNF receptor superfamily,member 6,TNFRSF 6,TNFRSF6,TNR6,Tumor necrosis factor receptor superfamily member 6,FAS抗体 |
| Swissprot | P25445,P25446,Q63199 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein corresponding to Mouse FasL |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:200-1:800 |
| Concentration | 1 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane, Membrane, Secreted |
| Tissue specificity | Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.Highest expression level in right ovary. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | FAS,also named as CD95,APO-1,APT1,FAS1 and TNFRSF6,is a receptor for TNFSF6/FASLG. It is a cell surface receptor belonging to the TNF receptor superfamily,can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains,leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance,in the antigen-stimulated suicide of mature T-cells,or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). This anti-Fas monoclonal antibody can be used to induce apoptosis in cell cultures through Fas by imitating the Fas-ligand. |
Images
Immunohistochemistry analysis of paraffin-embedded human appendix using FAS Polyclonal Antibody at dilution of 1:500.
Immunohistochemistry analysis of paraffin-embedded mouse Immunized spleen using FAS Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded mouse Immunized thymus using FAS Polyclonal Antibody at dilution of 1:300.
