Fetuin A/AHSG Polyclonal Antibody(Capture/Detector)
| 规格： | / 25μg / 100μg |
| 价格： | / 询价 / 询价 |
货号：AN003750P
货期：咨询
宿主: Rabbit
反应性: M
应用: ELISA Capture/Detector
Overview
| Synonyms | KUB;SGP;TRPM;NA1/NA;A2HS;AHS;alpha-2-HS-glycoprotein;APOJ;APO-J;CLI;Countertrypin;Fetuin-A;HSGA;KUB1;NA1/NA2;SGP2;SP-40;TRPM2;Fetua;Ahsg |
| Swissprot | P29699 |
| Source | Rabbit |
| Reactivity | Mouse |
| Immunogen | Recombinant Mouse Fetuin A/AHSG Protein expressed by Mammalian |
| Application | ELISA Capture/Detector |
| Recommended dilution | ELISA Capture,,2-8 μg/mL;ELISA Detector,,0.1-0.4 μg/mL |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Storage buffer | Sterile PBS ,pH 7.4 |
| Background | Fetuin-A, also named as Alpha2-HS glycoprotein (AHSG), is a member of cystatin superfamily of protease inhibitors. It is a highly expressed glycoprotein in various fetal tissues whereas it is mainly expressed by the liver in adults. Fetuin A, an extracellular inhibitor of transforming growth factor β, is a profibrogenic stimulus in liver disease. Circulating fetuin-A may be a beneficial serum biomarker in the detection of liver and vascular fibrosis progression in patients with non-alcoholic fatty liver disease. It is also involved in several functions, such as endocytosis, brain development and the formation of bone tissue. Fetuin-A exerts its effects on the cardiovascular system by two different mechanisms. On the one hand it inhibits ins signaling and induces ins resistance contributing to the onset of atherosclerosis and on the other hand it inhibits calcium deposition and protects from vascular calcification. |
