FZD8 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-16118
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | Frizzled 8 seven transmembrane spanning receptor,frizzled 8,seven transmembrane spanning receptor,Frizzled family receptor 8,frizzled homolog 8 (Drosophila),Frizzled homolog 8,Frizzled-8,FZ 8,Fz-8,FZ8,FZD 8,FZD8,FZD8,hFZ 8,hFz8,HGNC4046,Homolog of Drosophila Frizzled 8,FZD8抗体 |
| Swissprot | Q9H461 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human FZD8 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.2 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Membrane. Golgi apparatus. Cell membrane. Colocalizes with GOPC at the Golgi apparatus. |
| Tissue specificity | Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. |
