GAL3 PoLycLonaL Antibody
| 规格： | / 25ug / 100ug |
| 价格： | / ￥610 / ￥1640 |
货号：D-AB-10157L
货期：咨询
宿主: Rabbit
反应性: H,M
应用: IF,IHC
Overview
| Synonyms | GAL3;GaL-3;GaLectin-3;35 kDa Lectin;Carbohydrate-binding protein 35 (CBP 35);GaLactose-specific Lectin 3;GaLactoside-binding protein (GALBP);IgE-binding protein;LGALS3;MAC2 |
| Swissprot | P17931 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant Human GAL3 protein expressed by E.coLi |
| Application | IF,IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IF,,1:50-1:200; IHC,,1:650-1:1250 |
| Clonality | Polyclonal |
Properties
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Storeat-20℃ Valid for12months.Avoid freeze/thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4 |
| Background | Galactose-specific lectin which binds IgE. May mediate with the alpha-3,beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1,required for terminal differentiation of columnar epithelial cells during early embryogenesis.In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion,chemoattraction of monocytes macrophages,opsonization of apoptotic neutrophils,and activation of mast cells. Together with TRIM16,coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16l1 and BECN1 in response to damaged endomembranes. |
