GCG Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70318
宿主: Rabbit
反应性: M,R
应用: IHC,IF
Overview
| Synonyms | GCG,GLP 2,GLP1,GLP2,glucagon,GRPP,Glucagon like peptide 1,GRPP Oxyntomodulin,OXM,Proglucagon,GCG抗体 |
| Swissprot | P55095,P06883 |
| Source | Rabbit |
| Reactivity | Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse Glucagon |
| Application | IHC(Detection kit: E-IR-R213),IF |
| Recommended dilution | IHC,,1:500-1:1000;IF,,1:200-1:500; |
| Concentration | 1 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP-1 and GLP-2 are also secreted in selected neurons in the brain. |
| Tissue specificity | Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP-1 and GLP-2 are also secreted in selected neurons in the brain.Highest expression level in islet of Langerhans. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. |
Images
Immunohistochemistry analysis of paraffin-embedded mouse pancreas using GCG Polyclonal Antibody at dilution of 1:300.
Immunofluorescence analysis of paraffin-embedded Rat pancreas using GCG Polyclonal Antibody at dilution of 1:200.Red is labeled with glucagon antibody and green is labeled with insulin antibody.
Immunofluorescence analysis of paraffin-embedded Mouse pancreas using GCG Polyclonal Antibody at dilution of 1:200.Red is labeled with glucagon antibody and green is labeled with insulin antibody.
