GCK Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-40270
宿主: Rabbit
反应性: H,M
应用: WB,IHC,IF
Overview
| Synonyms | ATP:D-hexose 6-phosphotransferase,FGQTL3,GCK,GK,GLK,Glucokinase,Hexokinase D pancreatic isozyme,Hexokinase type IV,Hexokinase-4,Hexokinase-D,HHF3,HK IV,HK4,HKIV,HXK4,HXKP,LGLK,MODY2,GCK抗体 |
| Swissprot | P52792 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant Mouse Glucokinase protein |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),IF |
| Recommended dilution | WB,,1:1000-1:2000;IHC,,1:100-1:200;IF,,1:100-1:400; |
| Concentration | 1mg/mL |
Properties
| Cellular localization | Nucleus. Cytoplasm. |
| Tissue specificity | Isoform 1: Pancreas, anterior pituitary. Isoform 2: Liver.Highest expression level in liver |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4 |
| Background | Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). |
