GCK Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15062
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | ATP:D-hexose 6-phosphotransferase,FGQTL3,GCK,GK,GLK,Glucokinase,Hexokinase D pancreatic isozyme,Hexokinase type IV,Hexokinase-4,Hexokinase-D,HHF3,HK IV,HK4,HKIV,HXK4,HXKP,LGLK,MODY2,GCK抗体 |
| Swissprot | P35557 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human GCK |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100-1:300 |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytosol,Mitochondrion,Nucleus,nucleoplasm |
| Tissue specificity | Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). |
