GDNF Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70291
宿主: Rabbit
反应性: M,R
应用: IHC
Overview
| Synonyms | Astrocyte derived trophic factor,Astrocyte derived trophic factor 1,Astrocyte-derived trophic factor,ATF 1,ATF 2,Atf,ATF1,ATF2,gdnf,GDNF,Glial cell derived neurotrophic factor,Glial Cell Line Derived Neurotrophic Factor,Glial cell line-derived neurotrophic factor,Glial derived neurotrophic factor,HFB1 GDNF,hGDNF,HSCR3,GDNF抗体 |
| Swissprot | Q07731,P48540 |
| Source | Rabbit |
| Reactivity | Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to mouse GDNF |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100-1:500 |
| Concentration | 80 μg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted. |
| Tissue specificity | Expressed in both the central nervous system (CNS) and in non-CNS tissues, including the kidney, lung, bone, heart, liver, spleen, sciatic nerve and blood. In the brain, predominantly expressed in the striatum with Highest levels in the caudate and lowest in the putamen. Localizes at the proximal ligature of the hypoglossal nerve. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. |
