GRM3 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14110
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | GLUR3,Glutamate metabotropic receptor 3,Glutamate receptor metabotropic 3,GPRC1C,GRM3,GRM3,Metabotropic glutamate receptor 3,MGlu3,mGluR3,GRM3抗体 |
| Swissprot | Q14832 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human GRM3 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.2 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. |
| Tissue specificity | Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors.Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties.Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C.Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8.Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. |
