GSK3 alpha Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-12494
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | DKFZp686D0638,Glycogen synthase kinase 3 alpha,Glycogen synthase kinase-3 alpha,GSK 3 alpha,GSK 3A,GSK-3 alpha,Gsk3a,GSK3A,GSK3alpha,Serine/threonine protein kinase GSK3A,GSK3A抗体 |
| Swissprot | P49840 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human GSK3A |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytosol,Mitochondrion,Other locations:apical dendrite,beta-catenin destruction complex,neuronal cell body,postsynapse,proximal dendrite |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. |
