GSK3 beta Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70043
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC,IF
Overview
| Synonyms | Glycogen Synthase Kinase 3 Beta,Glycogen synthase kinase-3 beta,GSK 3 beta,GSK-3 beta,GSK3B,GSK3B,GSK3beta isoform,Serine/threonine-protein kinase GSK3B,GSK3 beta抗体 |
| Swissprot | P49841,Q9WV60,P18266 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse GSK3β |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),IF |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:300-1:800;IF,,1:200-1:500; |
| Concentration | 2 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Cell membrane. The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane. |
| Tissue specificity | Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain.Highest expression level in forebrain. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. |
Images
Western Blot analysis of various samples using GSK3 beta Polyclonal Antibody at dilution of 1:1000.
Immunohistochemistry analysis of paraffin-embedded human ovary cancer using GSK3 beta Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded mouse brain using GSK3 beta Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded rat testis using GSK3 beta Polyclonal Antibody at dilution of 1:300.
Immunofluorescence analysis of paraffin-embedded human liver cancer using GSK3 beta Polyclonal Antibody at dilution of 1:300.
