GSTM1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-40289
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC,IF
Overview
| Synonyms | GST class-mu 1, GST HB subunit 4, GST1, Gstm1, GSTM1a-1a, GTH4, GTM1, H-B, MU,GSTM1抗体 |
| Swissprot | P10649 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant Mouse Glutathione S-transferase Mu 1 protein |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),IF |
| Recommended dilution | WB 1:500-1:6000 IHC 1:100-1:200 IF 1:100-1:200 |
| Concentration | 0.54mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm |
| Tissue specificity | Highest expression level in urinary bladder urothelium |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% Proclin300, 50% glycerol, pH7.3. |
| Background | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. |
Images
Western Blot analysis of Mouse liver, Mouse heart, NIH/3T3, Jurkat, Rat kidney, Rat heart and Mouse kidney using GSTM1 Polyclonal Antibody at dilution of 1:500
Western Blot analysis of Hela cells using GSTM1 Polyclonal Antibody at dilution of 1:500
Immunohistochemistry of paraffin-embedded Human liver cancer using GSTM1 Polyclonal Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded Human kidney using GSTM1 Polyclonal Antibody at dilution of 1:100
Immunofluorescence analysis of Hela cells using GSTM1 Polyclonal Antibody at dilution of 1:100
