HACE1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-16474
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | E3 ubiquitin-protein ligase HACE1,HACE 1,HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1,KIAA1320,HACE1抗体 |
| Swissprot | Q8IYU2 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human HACE1 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100-1:200 |
| Concentration | 1.5mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasmic, Endoplasmic reticulum and Golgi Apparatus. A significant portion localizes to the endoplasmic reticulum. |
| Tissue specificity | Expressed in multiple tissues including heart, brain and kidney.1 Publication |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | HACE1 (HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1), also known as KIAA1320, is a 909 amino acid protein that localizes to both the cytoplasm and the endoplasmic reticulum and contains one HECT domain and six ANK repeats. Expressed in kidney, heart and brain, HACE1 functions as an E3 ubiquitin-protein ligase that interacts with the proteasome and is thought to play a role in protein degradation. HACE1 is downregulated in Wilms tumor, suggesting a possible role in tumor suppression. |
