HDAC1 Monoclonal Antibody
| 规格： | / 20μL / 60μL / 120μL |
| 价格： | / ￥580 / ￥1420 / ￥2310 |
货号：E-AB-22208
宿主: Mouse
反应性: H,M,R
应用: IHC-p
Overview
| Synonyms | DKFZp686H12203,GON 10,HD1,HDAC 1,HDAC1,HDAC1,Histone deacetylase 1,Reduced potassium dependency yeast homolog like 1,RPD3,RPD3L1,HDAC1 Mouse (4E1)抗体 |
| Swissprot | Q13547 |
| Source | Mouse |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic Peptide of HDAC1 |
| Application | IHC-p(Detection kit: E-IR-R213) |
| Recommended dilution | IHC 1:100-200 |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Cellular localization | Nucleus. |
| Tissue specificity | Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain. |
| Clone No | Clone:4E1 |
|---|---|
| Isotype | IgG |
| Purification | Protein A purification |
| Conjugation | HDAC1 Mouse Monoclonal Antibody |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4. |
| Background | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. |
