HIF1 alpha Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11289
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | ARNT interacting protein,ARNT-interacting protein,Basic helix loop helix PAS protein MOP1,Basic-helix-loop-helix-PAS protein MOP1,bHLHe78,Class E basic helix-loop-helix protein 78,HIF 1A,HIF 1alpha,HIF-1-alpha,HIF1 A,HIF1 Alpha,HIF1,HIF1-alpha,HIF1A,HIF1A,Hypoxia inducible factor 1 alpha,Hypoxia inducible factor 1 alpha isoform I.3,Hypoxia inducible factor 1 alpha subunit,Hypoxia inducible factor 1 alpha subunit basic helix loop helix transcription factor,Hypoxia inducible factor 1,alpha subunit (basic helix loop helix transcription factor),Hypoxia inducible factor1alpha,Hypoxia-inducible factor 1-alpha,Member of PAS protein 1,Member of PAS superfamily 1,Member of the PAS Superfamily 1,MOP 1,MOP1,PAS domain-containing protein 8,PASD 8,PASD8,HIF1A抗体 |
| Swissprot | Q16665 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human HIF1A |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.6 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Cytoplasmic in normoxia, nuclear translocation in response to hypoxia. Colocalizes with SUMO1 in the nucleus, under hypoxia. |
| Tissue specificity | Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. |
